Microfluidic cell culture systems / edited by Christopher Bettinger, Jeffrey T. Borenstein, Sarah L. Tao.

Pt. 1. Materials and fabrication methods. Microfluidic cell culture platforms with embedded nanoscale features -- Microvascular networks for tissue engineering -- Microfluidics for engineering 3D tissues and cellular microenvironments -- Fabrication of advanced microcontainer arrays for perfused 3D cell culture in microfluidic bioreactors -- Mechanobiological approaches for the control of cell motility -- Transport models for three-dimensional cell culture systems -- pt. 2. Tissue engineering strategies. Microfluidic systems for controlling stem cells microenvironments -- Vascularization of microfluidic hydrogels -- Microfluidic vascular networks for engineered tissues -- Microfluidic approaches toward pulmonary tissue constructs -- Microfabricated kidney tissue models -- Microfluidic cell culture techniques -- pt. 3. In vitro models. Functionalized microfluidic devices for separation of cell phenotypes -- Microfluidic hepatotoxicity platform -- Live cell analysis under shear flow -- Microfluidic platforms for evaluating angiogenesis and vasculogenesis -- Cardiovascular disease/discovery models.

The fields of microfluidics and BioMEMS are signigicantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. One of the key benefits of microfluidics for bioengineering is the ability to control parameters of the cell microenvironment at relevant length and time scales. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation, and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and bioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technolgies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications. Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture. Provides a balanced coverage of microsystems engineering and bioengineering.