TY  - BOOK
AU  - Dubey,Govind Prasad
AU  - Misra,Krishna
AU  - Kesharwani,Rajesh K.
AU  - Ojha,Rudra P.
TI  - Homocysteine Metabolism in Health and Disease
SN  - 9789811668678
U1  - 612 23
PY  - 2022///
CY  - Singapore
PB  - Springer Nature Singapore, Imprint: Springer
KW  - Human physiology
KW  - Metabolism
KW  - Nervous system-Diseases
KW  - Developmental neurobiology
KW  - Stem cells
KW  - Human Physiology
KW  - Neurological Disorders
KW  - Development of the Nervous System
KW  - Stem Cell Biology
N1  - Module 1 -- Nutrition and Health -- Module 2_Disease -- Module 3_Advanced Research
N2  - This book comprehensively reviews the association of homocysteine metabolism with the etiology of various human disorders. The well-defined chapters embedded the central and peripheral effects of homocysteine metabolism intricately related with cardiovascular, neurodegenerative, metabolic, and autoimmune disorders. Further, it discusses the mechanisms of perturbance of cellular proteostasis by elevated homocysteine levels and provides a comprehensive account of pathophysiological consequences and clinical implications of homocysteine-containing proteins. The book also reviews association of genetic variants of homocysteine metabolic genes with type 2 diabetes mellitus and obesity. It also describes the molecular mechanism of hyperhomocysteinemia in the negative/feedback regulation of neural stem cell proliferation and alterations in DNA methylation. Taken together, it summarizes the mechanisms of hyper homocysteinemia-induced endothelial dysfunction and physiological functions of hydrogen sulfide as the protective agent
UR  - https://doi.org/10.1007/978-981-16-6867-8
ER  -